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Drug addiction is a complex illness characterized by intense and, at times,
uncontrollable drug craving, along with compulsive drug seeking and use
that persist even in the face of devastating consequences. While the
path to drug addiction begins with the voluntary act of taking drugs,
over time a person's ability to choose not to do so becomes compromised,
and seeking and consuming the drug becomes compulsive. This behavior
results largely from the effects of prolonged drug exposure on brain
functioning.
Addiction is a brain disease that affects multiple brain
circuits, including those involved in reward and motivation, learning
and memory, and inhibitory control over behavior.
Because
drug abuse and addiction have so many dimensions and disrupt so many aspects
of an individual's life, treatment is not simple. Effective treatment
programs typically incorporate many components, each directed to a
particular aspect of the illness and its consequences.
Addiction treatment must help the individual stop using drugs, maintain a
drug-free lifestyle, and achieve productive functioning in the family,
at work, and in society. Because addiction is typically a chronic
disease, people cannot simply stop using drugs for a few days and be
cured. Most patients require long-term or repeated episodes of care to
achieve the ultimate goal of sustained abstinence and recovery of their
lives.
Principles of Effective Treatment
Scientific
research since the mid–1970s shows that treatment can help patients
addicted to drugs stop using, avoid relapse, and successfully recover
their lives. Based on this research, key principles have emerged that
should form the basis of any effective treatment programs:
Addiction is a complex but treatable disease that affects brain function and behavior.
No single treatment is appropriate for everyone.
Treatment needs to be readily available.
Effective treatment attends to multiple needs of the individual, not just his or her drug abuse.
Remaining in treatment for an adequate period of time is critical.
Counseling—individual and/or group—and other behavioral therapies are the most commonly used forms of drug abuse treatment.
Medications
are an important element of treatment for many patients, especially
when combined with counseling and other behavioral therapies.
An
individual's treatment and services plan must be assessed continually
and modified as necessary to ensure that it meets his or her changing
needs.
Many drug–addicted individuals also have other mental disorders.
Medically
assisted detoxification is only the first stage of addiction treatment
and by itself does little to change long–term drug abuse.
Treatment does not need to be voluntary to be effective.
Drug use during treatment must be monitored continuously, as lapses during treatment do occur.
Treatment
programs should assess patients for the presence of HIV/AIDS, hepatitis
B and C, tuberculosis, and other infectious diseases as well as provide
targeted risk–reduction counseling to help patients modify or change
behaviors that place them at risk of contracting or spreading infectious
diseases.
Effective Treatment Approaches
Medication and
behavioral therapy, especially when combined, are important elements of
an overall therapeutic process that often begins with detoxification,
followed by treatment and relapse prevention. Easing withdrawal symptoms
can be important in the initiation of treatment; preventing relapse is
necessary for maintaining its effects. And sometimes, as with other
chronic conditions, episodes of relapse may require a return to prior
treatment components. A continuum of care that includes a customized
treatment regimen—addressing all aspects of an individual's life,
including medical and mental health services—and follow–up options
(e.g., community – or family-based recovery support systems) can be
crucial to a person's success in achieving and maintaining a drug–free
lifestyle.
Medications
Medications can be used to help with different aspects of the treatment process.
Withdrawal.
Medications offer help in suppressing withdrawal symptoms during
detoxification. However, medically assisted detoxification is not in
itself "treatment"—it is only the first step in the treatment process.
Patients who go through medically assisted withdrawal but do not receive
any further treatment show drug abuse patterns similar to those who
were never treated.
Treatment. Medications can be used to
help reestablish normal brain function and to prevent relapse and
diminish cravings. Currently, we have medications for opioids (heroin,
morphine), tobacco (nicotine), and alcohol addiction and are developing
others for treating stimulant (cocaine, methamphetamine) and cannabis
(marijuana) addiction. Most people with severe addiction problems,
however, are polydrug users (users of more than one drug) and will
require treatment for all of the substances that they abuse.
Opioids: Methadone,
buprenorphine and, for some individuals, naltrexone are effective
medications for the treatment of opiate addiction. Acting on the same
targets in the brain as heroin and morphine, methadone and buprenorphine
suppress withdrawal symptoms and relieve cravings. Naltrexone works by
blocking the effects of heroin or other opioids at their receptor sites
and should only be used in patients who have already been detoxified.
Because of compliance issues, naltrexone is not as widely used as the
other medications. All medications help patients disengage from drug
seeking and related criminal behavior and become more receptive to
behavioral treatments.
Tobacco: A variety of
formulations of nicotine replacement therapies now exist—including the
patch, spray, gum, and lozenges—that are available over the counter. In
addition, two prescription medications have been FDA–approved for
tobacco addiction: bupropion and varenicline. They have different
mechanisms of action in the brain, but both help prevent relapse in
people trying to quit. Each of the above medications is recommended for
use in combination with behavioral treatments, including group and
individual therapies, as well as telephone quitlines.
Alcohol:
Three medications have been FDA–approved for treating alcohol
dependence: naltrexone, acamprosate, and disulfiram. A fourth,
topiramate, is showing encouraging results in clinical trials.
Naltrexone blocks opioid receptors that are involved in the rewarding
effects of drinking and in the craving for alcohol. It reduces relapse
to heavy drinking and is highly effective in some but not all
patients—this is likely related to genetic differences. Acamprosate is
thought to reduce symptoms of protracted withdrawal, such as insomnia,
anxiety, restlessness, and dysphoria (an unpleasant or uncomfortable
emotional state, such as depression, anxiety, or irritability). It may
be more effective in patients with severe dependence. Disulfiram
interferes with the degradation of alcohol, resulting in the
accumulation of acetaldehyde, which, in turn, produces a very unpleasant
reaction that includes flushing, nausea, and palpitations if the
patient drinks alcohol. Compliance can be a problem, but among patients
who are highly motivated, disulfiram can be very effective.
Behavioral Treatments
Behavioral
treatments help patients engage in the treatment process, modify their
attitudes and behaviors related to drug abuse, and increase healthy life
skills. These treatments can also enhance the effectiveness of
medications and help people stay in treatment longer. Treatment for drug
abuse and addiction can be delivered in many different settings using a
variety of behavioral approaches.
Outpatient behavioral
treatment encompasses a wide variety of programs for patients who visit a
clinic at regular intervals. Most of the programs involve individual or
group drug counseling. Some programs also offer other forms of
behavioral treatment such as—
Cognitive–behavioral therapy,
which seeks to help patients recognize, avoid, and cope with the
situations in which they are most likely to abuse drugs.
Multidimensional
family therapy, which was developed for adolescents with drug abuse
problems—as well as their families—addresses a range of influences on
their drug abuse patterns and is designed to improve overall family
functioning.
Motivational interviewing, which capitalizes on the readiness of individuals to change their behavior and enter treatment.
Motivational incentives (contingency management), which uses positive reinforcement to encourage abstinence from drugs.